Cancer risk in primary sclerosing cholangitis (PSC) Hepatocellular carcinoma: 0.3%-2.8% lifetime incidence Gallbladder carcinoma: 1%-3.5% lifetime incidence (10x general population) Cholangiocarcinoma: up to 20% lifetime incidence (400x-1500x general population) Colorectal cancer: 20-30% lifetime incidence in PSC-IBD (10x risk general population, 4x risk over UC) References: Fung BM, Lindor KD, Tabibian JH. Cancer risk in primary ..
Category : Hepatology
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis Diagnosis of Acute Cholangitis Acute cholangitis is typically diagnosed based on clinical presentation, laboratory tests, and imaging studies. The Tokyo Guidelines propose the following diagnostic criteria: Diagnostic Criteria To establish a diagnosis, the presence of one item in each of the ..
The Leipzig score for Wilson’s disease is a diagnostic tool that combines various clinical, biochemical, and genetic criteria to assess the likelihood of the disease. This scoring system was developed at the 8th International Meeting on Wilson’s Disease in Leipzig in 2001 and has been incorporated into clinical practice guidelines by the European Association for ..
EASL guideline Primary Biliary Cholangitis management flow chart References: https://easl.eu/wp-content/uploads/2018/10/PBC-English-..
Milan Criteria for Liver Transplantation in HCC Patients meeting the Milan Criteria generally have a better prognosis after liver transplantation, with a post-transplant 5-year survival rate exceeding 70%. The criteria have become a standard for assessing transplant eligibility in many centers worldwide. The Milan Criteria were originally proposed in 1996 by Dr. Vincenzo Mazzaferro and ..
Extended criteria (liver) donor (ECD) Related articles:Liver transplantation criteria for HCCKing’s College criteria for liver transplantationRisk of liver decompensation after hepatectomy Definition of ECD donorsThe ECD graft represents an organ with unfavourable characteristicsassociated with suboptimal post-transplant outcomes thatfall into two main risk categories: poor graft function and potentialfor disease transmission. Within the poor graft function ..